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Close to eighty% of TTP is induced by deficient exercise of ADAMTS13. ADAMTS13 deficiency could be constitutive, due to biallelic ADAMTS13 pathogenic variants; or obtained, as a result of an inhibitory antibody. Evaluation of ADAMTS13 action is executed utilizing exams based upon the aptitude in the protease to cleave common VWF multimers in vitro
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